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KMID : 1098420100180040224
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Korean Journal of Medicinal Crop Science
2010 Volume.18 No. 4 p.224 ~ p.230
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Anti-Oxidative and Anti-Inflammatory Effects of Green Tea Mixture and Dietary Fiber on Liver of High Fat Diet-Induced Obese Rats
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Kim Jong-Dai
Lee Byung-Il
Jeon Yun-Hui
Park Jong-Phil
Kim Hae-Ran
Lim Beong-Ou
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Abstract
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This study was conducted to investigate anti-oxidative and inflammatory inhibition effects of green tea and dietary fiber mixture on liver of high fat diet-induced obese rats. 21 male rats were divided into 3 dietary groups and control group (A), high fat diet-induced group (B), and high fat (HF) diet-induced + EQ diet-S® diet group (C). Immunoblotting and RT-PCR analysis revealed protein expression, and anti-oxidant analysis revealed MDA (malondialdehyde), GSH (glutathione), and free DPPH radical. As a results, Body weight and food consumption were not significantly different between groups. The levels of MDA and GSH were lower in HF + EQS® group than in HF group. Also, the EQS® demonstrated to be more effective than HF group for a DPPH radicals scavenging activities. In addition, protein and mRNA level of TNF-α in HF + EQS® group showed relatively more potent pro-inflammatory activity inhibition compared to HF group. These results suggest that green tea mixture (EQ diet-S®) provide positive effects on anti-oxidative and inflammatory inhibition effects on obese animal model or obesity related diseases.
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KEYWORD
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High Fat, Green tea, MDA, GSH, DPPH, TNF-α
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